Synthetic Studies on 2-N-Substituted Cephems. III. Reaction of 2-Azido-3-cephems and 2-Azido-2-cephems
نویسندگان
چکیده
منابع مشابه
Synthesis and structure-activity relationships of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephems with C-3 substitutions.
Synthesis and biological activity of a series of 7 beta-[(Z)-2-(2- aminothiazol-4-yl)-3-(substituted)-2-propenoylamino]-3-cephe m-4-carboxylic acids with C-3 substitutions and their pivaloyloxymethyl esters are described. These acid compounds exhibited potent antibacterial activity against both Gram-positive and Gram-negative bacteria. Pivaloyloxymethyl esters of selected compounds in this seri...
متن کاملDicyclohexylammonium (S)-2-azido-3-phenylpropanoate
The asymmetric unit of the title compound, C(12)H(24)N(+)·C(9)H(8)N(3)O(2) (-), consists of two dicyclo-hexyl-ammonium cations linked to two (S)-2-azido-3-phenyl-propano-ate anions by four short N-H⋯O hydrogen bonds with N⋯O distances in the range 2.712 (3)-2.765 (3) Å. The dicyclo-hexyl-ammonium cations and the aryl and carboxyl-ate groups of the anion are related by a pseudo-inversion centre,...
متن کاملIntracellular metabolism of CycloSaligenyl 3'-azido-2', 3'-dideoxythymidine monophosphate, a prodrug of 3'-azido-2', 3'-dideoxythymidine (zidovudine).
The administration of CycloSaligenyl 3'-azido-2',3'-dideoxythymidine monophosphate (CycloSal-AZTMP) to CEM cells resulted in a concentration- and time-dependent conversion to the 5'-monophosphate (AZTMP), 5'-diphosphate (AZTDP), and 5'-triphosphate (AZTTP) derivatives. High ratios of AZTMP/AZTTP were found in the CEM cell cultures treated with CycloSal-AZTMP. The intracellular T(1/2) of AZTTP i...
متن کاملTetrakis(azido-κN)(di-2-pyridylamine-κ2 N 2,N 2′)platinum(IV)
In the title complex, [Pt(N(3))(4)(C(10)H(9)N(3))], the Pt(IV) ion is six-coordinated in a slightly distorted octa-hedral environment by the two pyridine N atoms of the chelating di-2-pyridyl-amine (dpa) ligand and four N atoms from four azide anions. The dpa ligand is not planar, the dihedral angle between the pyridine rings being 20.0 (3)°. The azide ligands are slightly bent [N-N-N = 173.5 (...
متن کاملBis(azido-κN)(di-2-pyridylamine-κ2 N 2,N 2′)palladium(II)
In the title complex, [Pd(N(3))(2)(C(10)H(9)N(3))], the Pd(II) ion is in a slightly distorted square-planar coordination environment. The ligator atoms comprise the two pyridine N atoms of the chelating di-2-pyridyl-amine (dpa) ligand and two N atoms from two azide anions. The dpa ligand coordinates the Pd atom in a boat conformation, the dihedral angle between the pyridine rings being 24.4 (1)...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1982
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.102.9_844